All About Diseases

In addition, one study has showed bradykinin to be more sensitive than methacholine, and another study in children showed cold air to be more sensitive than methacholine. The studies that have not shown any difference between indirect and direct challenges in demonstrating the effects of ICS have … Continue reading →

Discussion This study shows that histamine and mannitol challenges are equally sensitive tests to demonstrate the effect of ICS on bronchial responsiveness. To explore the validity of the tests to demonstrate the healing process of asthma by inhaled budes-onide, the … Continue reading →

The change in RDR values are expressed as log RDR during treatment minus log RDR at baseline. PD15 values are mainly used in descriptive results due to their familiarity to clinicians; however, RDR values were used for comparisons between the challenges and correlation analysis … Continue reading →

Many other drugs potentiate the anticoagulant effect of warfarin by inhibiting its clearance through stereoselective or nonselective pathways. Stereoselective interactions may affect the oxidative metabolism of either the S-isomer or R-isomer of warfarin. The inhibition of S-warfarin metabolism is more important clinically, … Continue reading →

Genetic factors include the following. (1) There is a common mutation in the gene coding for the cytochrome P450 2C9 hepatic microsomal enzyme that is responsible for the oxidative metabolism of the more potent warfarin S-isomer. This mutation is independently responsible for … Continue reading →

The VKAs produce their anticoagulant effect by interfering with the cyclic interconversion of vitamin K and its 2,3 epoxide (vitamin K epoxide), thereby modulating the y-carboxylation of glutamate residues (Gla) on the N-terminal regions of vitamin K-dependent proteins (Fig 1). The … Continue reading →